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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FOXO1 All Species: 14.85
Human Site: S432 Identified Species: 32.67
UniProt: Q12778 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q12778 NP_002006.2 655 69662 S432 T Y G Q S S M S P L P Q M P I
Chimpanzee Pan troglodytes XP_522749 829 87557 S606 T Y G Q S S M S P L P Q M P I
Rhesus Macaque Macaca mulatta XP_001088437 860 91177 N637 T Y G Q S S M N P L P Q M P M
Dog Lupus familis XP_534487 524 56894 L303 G Q S S M S P L P Q M P M Q T
Cat Felis silvestris
Mouse Mus musculus Q9R1E0 652 69484 S429 T Y G Q S S M S P L P Q M P M
Rat Rattus norvegicus XP_342245 649 69326 S426 T Y G Q S S M S P V P Q M P M
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512968 514 54918 A293 R K F P Y G Q A G L S P L P Q
Chicken Gallus gallus Q90964 451 48838 G230 S D D V F I G G T T G K L R R
Frog Xenopus laevis Q6EUW2 631 68449 R406 G S P N S E Y R K Y S Y A Q T
Zebra Danio Brachydanio rerio NP_001070725 652 69329 M425 G M G S M S P M P M Q P L P E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q95V55 613 67394 S392 R D G L S P N S V T T T M S P
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 79 75.4 74.8 N.A. 92.6 92.2 N.A. 63.3 21.9 66.4 59.3 N.A. 29.7 N.A. N.A. N.A.
Protein Similarity: 100 79 75.6 77.2 N.A. 95.5 95.2 N.A. 69.9 35.4 76.7 72 N.A. 41.9 N.A. N.A. N.A.
P-Site Identity: 100 100 86.6 20 N.A. 93.3 86.6 N.A. 13.3 0 6.6 26.6 N.A. 26.6 N.A. N.A. N.A.
P-Site Similarity: 100 100 100 20 N.A. 100 100 N.A. 26.6 20 6.6 40 N.A. 26.6 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 10 0 0 0 0 10 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 19 10 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 10 % E
% Phe: 0 0 10 0 10 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 28 0 64 0 0 10 10 10 10 0 10 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 19 % I
% Lys: 0 10 0 0 0 0 0 0 10 0 0 10 0 0 0 % K
% Leu: 0 0 0 10 0 0 0 10 0 46 0 0 28 0 0 % L
% Met: 0 10 0 0 19 0 46 10 0 10 10 0 64 0 28 % M
% Asn: 0 0 0 10 0 0 10 10 0 0 0 0 0 0 0 % N
% Pro: 0 0 10 10 0 10 19 0 64 0 46 28 0 64 10 % P
% Gln: 0 10 0 46 0 0 10 0 0 10 10 46 0 19 10 % Q
% Arg: 19 0 0 0 0 0 0 10 0 0 0 0 0 10 10 % R
% Ser: 10 10 10 19 64 64 0 46 0 0 19 0 0 10 0 % S
% Thr: 46 0 0 0 0 0 0 0 10 19 10 10 0 0 19 % T
% Val: 0 0 0 10 0 0 0 0 10 10 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 46 0 0 10 0 10 0 0 10 0 10 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _